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In OFDMA systems, reducing the inter-cell interference among adjacent cells is a very important issue especially for the cell-edge users. In this paper, we propose a distributed algorithm that maximizing the system total throughput considering proportional fairness. In our proposed algorithm, the frequency resources in each cell is divided into high and low power regions. The bandwidth allocations within a cell is adapted on a large-time scale, while the transmission power is adapted on a small-time scale, so as to be practical for dynamic scheduling. The proposed algorithm only needs limited inter-cell coordination, and guarantees the fairness among different users and cells. Simulation results show that our proposed algorithm converges quickly and achieves good throughput compared with other algorithms.