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Abstract-This paper presents a semi-analytical method to predict the performance of iterative interference cancellers used in advanced multiuser MIMO CDMA systems. At the receiver side, the orthogonality between codes is restored by a chip rate equalization allowing the transmitted symbols to be subsequently estimated by a simple correlations. The proposed prediction method is based on Signal to Interference-plus-Noise Ratio (SINR) tracking and Average Mutual Information (AMI) compression. Therefore, the SINR at symbol level after despreading is analytically derived and injected into the algorithm. Simulations confirm that the method provides accurate performance prediction and is fast enough to be integrated in radio resource management and link adaptation mechanisms of advanced MIMO CDMA/MC-CDMA systems using powerful interference cancellation techniques.