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Spatial and Temporal-Controlled Tissue Heating on a Modified Clinical Ultrasound Scanner for Generating Mild Hyperthermia in Tumors

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7 Author(s)
Kruse, D.E. ; Dept. of Biomed. Eng., Univ. of California, Davis, CA, USA ; Chun-Yen Lai ; Stephens, D.N. ; Sutcliffe, P.
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A new system is presented for generating controlled tissue heating with a clinical ultrasound scanner, and initial in vitro and in vivo results are presented that demonstrate both transient and sustained heating in the mild-hyperthermia range of 37°C-42°C. The system consists of a Siemens Antares ultrasound scanner, a custom dual-frequency three-row transducer array and an external temperature feedback control system. The transducer has two outer rows that operate at 1.5 MHz for tissue heating and a center row that operates at 5 MHz for B-mode imaging to guide the therapy. We compare the field maps obtained using a hydrophone against calculations of the ultrasound beam based on monochromatic and linear assumptions. Using the finite-difference time-domain (FDTD) method, we compare predicted time-dependent thermal profiles to measured profiles for soy tofu as a tissue-mimicking phantom. In vitro results show differential heating of 6°C for chicken breast and tofu. In vivo tests of the system were performed on three mice bearing Met-1 tumors, which is a model of aggressive, metastatic, and highly vascular breast cancer. In superficially implanted tumors, we demonstrate controlled heating to 42°C. We show that the system is able to maintain the temperature to within 0.1°C of the desired temperature both in vitro and in vivo.

Published in:

Biomedical Engineering, IEEE Transactions on  (Volume:57 ,  Issue: 1 )

Date of Publication:

Jan. 2010

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