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Can playing a video game help save lives? It might seem unlikely, especially if the first image that comes to mind at the word "gamer" is that of an overstimulated, underdeveloped teenager who desperately needs a suntan and a girlfriend. However, like many of today's gamers, video games are moving out of their parents' basement and into the real world. Video games are maturing and facing adaptation to serious applications. Such serious games are seeing use in a variety of fields, from the military to corporate management, and are finally being employed in healthcare. One of the biggest, most challenging areas is modeling simulations for medical training, particularly for managing chronic illness and providing system-level population-based care.