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When designing a neural or fuzzy system, a careful preprocessing of the database is of utmost importance in order to produce a trustable system. In function approximation applications, when a functional relationship between input and output variables is supposed to exist, the presence of data where the similar set of input variables is associated to very different values of the output is not always beneficial for the final system to design. A method is presented which can be used to detect anomalous data, namely non-coherent associations between input and output patterns. This technique, by mean of a comparison between two distance matrix associated to the input and output patterns, is able to detect elements in a dataset, where similar values of input variables are associated to quite different output values. A numerical example and a more complex application in the pre-processing of data coming from an industrial database were presented.