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In this article, an innovation pole is defined as a regional industrial innovation subsystem producing dense innovative activities, being representative in innovation scale, and driving the development of regional economy. We regard the regional innovation system as a symbiosis evolution system of the multi-innovation poles. Then, using of the theory and methods of ecology, this article analyses the symbiosis evolution model of multi-innovation poles and builds up the dynamics model of the multi-innovation poles symbiosis evolution system. Finally, we draw a conclusion through the simulation study that: different values of symbiosis coefficient are the only difference between regional innovation systems besides the strength or weakness of innovation poles.