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The development of earthquake disaster reduction system (EDRS) depends on the state of arts of computer technology, involving many fields of computer application skills and techniques. In this paper, first a key period after earth quake occurrence is discussed. Then a Web GIS based information and decision-making support system (the system) for earthquake disaster reduction is introduced, including of technical frame works, function composition, structure of software, redevelopment languages, data bases, and remote linking and calling of analysis modules. Mean while tested by a Ms5.1 earthquake in north-east China, the system showed the damage distribution maps, which include the comparison of isoseismals map and the damage of buildings map. Finally, several conclusions are presented.