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A benchtop, ultrafast infrared spectroscopic imaging system for biomedical applications

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3 Author(s)
Amrania, Hemmel ; Department of Physics, Experimental Solid State Group, Imperial College, London SW7 2AZ, United Kingdom ; McCrow, Andrew ; Phillips, Chris

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We discuss the potential biomedical applications for a novel infrared spectroscopic microimaging system. A tunable, table top solid-state laser has been coupled to a commercial infrared microscope, fitted with a modified high resolution infrared camera, to create a unique tool for midinfrared imaging. The system is capable of performing broadband imaging at a diffraction-limited spatial resolution, as is demonstrated here by spatially resolved spectroscopy of polymer test samples with a spectral resolution of 20 cm-1. The large pulse energies (tens of microjoules) offer previously unobtainable combinations of high signal-to-noise levels and rapid data collection times which are superior to current stand-alone laboratory instruments by many decades. Coupled with the short (100 ps) short pulse duration, these characteristics promise to make a wide range of time-resolved and reflection mode imaging experiments possible with live biological systems.

Published in:

Review of Scientific Instruments  (Volume:80 ,  Issue: 12 )