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To fully realize the benefit of ontology-driven Â¿OmicsÂ¿ data integration, it is essential that database management systems (DBMSs) provide persistent storage and efficient concurrent access in a manner that leverages the emerging Semantic Web technologies. In this paper, we explore the current capabilities of existing DBMSs, such as Oracle's database server, to meet the needs generated by the Semantic Web technologies. Our primary consideration is the new features provided by existing DBMSs to incorporate RDF, OWL, and SPARQL. We present a framework for this evaluation and lay the groundwork for subsequent benchmarking of the semantic-enabled DBMSs.