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The multi-carrier code-division multiple-access (MC-CDMA) multiple-input multiple-output (MIMO) system with quasi-orthogonal space-time block codes (QO-STBC) is studied in this paper. Considering QO-STBC scheme that involves three or four transmit antennas, a subspace-based blind channel estimation is proposed. With the estimated channel coefficients, the minimum output energy (MOE) and eigenspace receivers are employed for symbol detection. The weight analyses are performed to reduce the system computational complexity. Besides, the forward backward averaging technique is presented to enhance the performance of multiuser detection.