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This paper highlights engineering accomplishments from 1942 to present, in the Los Angeles area, starting from the San Fernando Valley, one of the major bases in the defense industry, to as far reaching as San Diego. Historical advancements in microwave, space programs, computer and communications have opened up collaborations toward green and smart energy, and complex software. Leading technology change and entrepreneurship development under economic pressure have been reflected in these events. Trends and milestones are revealed through collective efforts of many outstanding individuals in the greater Los Angeles area.