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Self-assembled monolayer (SAM) techniques offer a new strategy for the immobilization of antibodies, antigens and DNA on the surface of quartz crystal electrodes. The quartz crystal microbalance (QCM) system provides a unique opportunity to monitor, in-situ and in real-time, the rate of adsorption of ethanthiol onto gold. The change in frequency resulting from the adsorption of ethanthiol molecules onto the gold electrode of a QCM crystal allows direct measurement of the rate of formation of Self Assembled Monolayer (SAMs). The IR spectroscopy with attenuated total reflectance (ATR) confirms the formation of the Au-thiolate bonds in the CH stretching region.