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In this article, we investigate the influence of acute exposure to 2-aminoethoxy-diphenylborate (2-APB), a membrane-permeable inositol 1,4,5-trisphosphate (IP3) receptor, and store-operated Ca2+ channel (SOC) blocker on the complexity of hippocampal gamma oscillations. Our central hypothesis is that acute exposure to 2-APB significantly reduces the hippocampal gamma oscillations. To test this hypothesis, we use brain-slice recordings and the advanced nonlinear dynamical analysis method based on the Lempel-Ziv (LZ) estimator. Our nonlinear dynamical analysis results estimated from brain-slice recordings suggested that 2-APB exposure significantly reduces the hippocampal gamma oscillations.