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In this paper, a reconfigurable, low-power Application Specific Integrated Circuit (ASIC) that extracts and transmits electrocardiograph (ECG) signals is presented. An intelligent electrode is introduced which consists of the proposed ASIC and a micro spike array, permitting onsite ECG signal acquisition, processing and transmission. Fabricated in a standard 0.18 mum CMOS process, the ASIC consumes 78 muW with 1.0 V core voltage at 6 MHz operating frequency and only occupies 2.25 mm2. The tiny silicon size makes it possible and suitable to embed the proposed ASIC into an intelligent electrode, and the low power consumption makes it feasible for long term continuous ECG monitoring.