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Injectable myocardial matrix as a scaffold for myocardial tissue engineering

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3 Author(s)
Jennifer M. Singelyn ; Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 USA ; Jessica A. DeQuach ; Karen L. Christman

Current injectable materials utilized in myocardial tissue engineering have been borrowed from other tissue engineering applications and have not been specifically designed for the myocardium. We have recently tested the feasibility of using an injectable form of myocardial extracellular matrix that would provide cardiac specific matrix cues as well as be amenable to minimally invasive delivery. We have demonstrated that this material self-assembles in vivo to form a nanofibrous scaffold, which supports the infiltration of neovasculature. We have also demonstrated that this material may be delivered minimally invasively through a catheter.

Published in:

2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society

Date of Conference:

3-6 Sept. 2009