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A personalized and optimal approach for dosing contrast material at coronary computed tomography angiography

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4 Author(s)
Kalafut, J.F. ; MEDRAD Inc., Indianola, PA, USA ; Kemper, C.A. ; Suryani, P. ; Schoepf, U.J.

A method for constructing a personalized contrast medium protocol at contrast enhanced, Coronary CT Angiography (CCTA) is presented. A one compartment pharmacokinetic model is parameterized and identified with a minimal data set from a test-bolus injection. A direct-search optimization is performed to construct a protocol that achieves target enhancement in the cardiac structures. Clinical results demonstrating the method's ability to achieve prospectively chosen image enhancement levels while reducing contrast medium dose are presented.

Published in:

Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE

Date of Conference:

3-6 Sept. 2009