By Topic

Using an open-loop inverse control strategy to regulate CA1 nonlinear dynamics for an in vitro hippocampal prosthesis model

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

3 Author(s)
Min-Chi Hsiao ; Dept. of Biomed. Eng., Univ. of Southern California (USC), Los Angeles, CA, USA ; Dong Song ; Berger, T.W.

A modeling-control paradigm to regulate output of the hippocampus (CA1) for a hippocampal neuroprosthesis was developed and validated using an in vitro slice preparation. Our previous study has shown that the VLSI implementation of a CA3 nonlinear dynamic model can functionally replace the CA3 subregion of the hippocampal slice. The propagation of temporal patterns of activity from DGrarrVLSIrarrCA1 reproduces the activity observed experimentally in the biological DGrarrCA3rarrCA1 circuit. In this project, we incorporate an open-loop controller to optimize the output (CA1) response. Specifically, we seek to optimize the stimulation signal to CA1 using a predictive dentate gyrus (DG)-CA1 nonlinear model (i.e., DG-CA1 trajectory model) and a CA1 input-output model (i.e., CA1 plant model), such that the ultimate CA1 response (i.e., desired output) can be first predicted by the DG-CA1 trajectory model and then transformed to the desired stimulation intensity through the CA1 inverse plant model. Laguerre-Volterra kernel model for random - interval, graded - input, contemporaneous - graded -output system is formulated and applied to build the DG-CA1 trajectory model and the CA1 plant model. The inverse model to transform desired output to input is also derived and validated. We validated the paradigm in hippocampal slices, and results showed the CA1 response evoked by the controlled stimulation signal reinstated the CA1 response evoked by the trisynaptic pathway.

Published in:

Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE

Date of Conference:

3-6 Sept. 2009