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Multiscale finite element modeling of the lamina cribrosa microarchitecture in the eye

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4 Author(s)
Downs, J.C. ; Ocular Biomech. Lab., Devers Eye Inst., Portland, OR, USA ; Roberts, M.D. ; Burgoyne, C.F. ; Hart, R.T.

In this paper, we describe a new method for constructing macro-scale models of the posterior pole of the eye to investigate the role of intraocular pressure in the development and progression of glaucoma. We also describe a method and present results from micro-scale finite element models of the lamina cribrosa microarchitecture that are derived from parent macro-scale continuum models using a novel multiscale substructuring approach. The laminar micro-scale models capture the biomechanical behavior of the laminar trabeculae in a way that cannot be estimated using macro-scale techniques, and predict much higher stresses and strains than those calculated within macro-scale models of the coincident region in the same eye.

Published in:

Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE

Date of Conference:

3-6 Sept. 2009