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Browse Journals & Magazines > Electron Devices, IEEE Transa ...> Volume:57 Issue:1 Help

LED-Based Optical Device for Chronic In Vivo Cerebral Blood Volume Measurement

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6 Author(s)
Cox, Marshall P. ; Dept. of Electr. Eng., Columbia Univ., New York, NY, USA ; Hongtao Ma ; Bahlke, M.E. ; Beck, J.H.
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We demonstrate a reflectivity-based cerebral blood volume sensor comprised of surface-mount light-emitting diodes on a flexible substrate with integrated photodetectors in a form factor suitable for direct brain contact and chronic implantation. This reflectivity monitor is able to measure blood flow through the change of the surface reflectivity and, through this mechanism, detect the cerebral-blood-volume changes associated with epileptic seizures with a signal-to-noise (SNR) response of 42 dB. The device is tested in an in vivo model confirming its compatibility and sensitivity. The data taken demonstrate that placing the sensor into direct brain contact improves the SNR by more than four orders of magnitude over current noncontact technologies.

Published in:
Electron Devices, IEEE Transactions on  (Volume:57 ,  Issue: 1 )

Date of Publication: Jan. 2010

Page(s):
174 - 177
ISSN :
0018-9383
INSPEC Accession Number:
11024608
Digital Object Identifier :
10.1109/TED.2009.2033652
Date of Publication :
10 November 2009
Date of Current Version :
22 December 2009
Issue Date :
Jan. 2010
Sponsored by :
IEEE Electron Devices Society

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