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Time, cost, quality, and safety, with mutual influence, are the four major control items for project management. The best solution for a project is to achieve high quality with low cost in a proper time limit and without safe accident. Based on the comprehensive limitations above, an integrated optimization model is build up, which can balance the construction time-cost-quality-safety systematically in different risk level in order to archive the most satisfactory goals or several approximately perfect plans as alternatives. Through the optimizing the overall economic benefit of construction project is enhanced. Finally an instance, office building project, is carried out to show the validity of the model.