By Topic

Wireless Micropower Instrumentation for Multimodal Acquisition of Electrical and Chemical Neural Activity

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

4 Author(s)
Mollazadeh, M. ; Biomed. Eng. Dept., Johns Hopkins Univ., Baltimore, MD, USA ; Murari, K. ; Cauwenberghs, G. ; Thakor, N.

The intricate coupling between electrical and chemical activity in neural pathways of the central nervous system, and the implication of this coupling in neuropathologies, such as Parkinson's disease, motivates simultaneous monitoring of neurochemical and neuropotential signals. However, to date, neurochemical sensing has been lacking in integrated clinical instrumentation as well as in brain-computer interfaces (BCI). Here, we present an integrated system capable of continuous acquisition of data modalities in awake, behaving subjects. It features one channel each of a configurable neuropotential and a neurochemical acquisition system. The electrophysiological channel is comprised of a 40-dB gain, fully differential amplifier with tunable bandwidth from 140 Hz to 8.2 kHz. The amplifier offers input-referred noise below 2 muV rms for all bandwidth settings. The neurochemical module features a picoampere sensitivity potentiostat with a dynamic range spanning six decades from picoamperes to microamperes. Both systems have independent on-chip, configurable DeltaSigma analog-to-digital converters (ADCs) with programmable digital gain and resolution. The system was also interfaced to a wireless power harvesting and telemetry module capable of powering up the circuits, providing clocks for ADC operation, and telemetering out the data at up to 32 kb/s over 3.5 cm with a bit-error rate of less than 10-5. Characterization and experimental results from the electrophysiological and neurochemical modules as well as the full system are presented.

Published in:

Biomedical Circuits and Systems, IEEE Transactions on  (Volume:3 ,  Issue: 6 )