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Statistical Analysis of Gene Co-Expression Networks by Maximal Overlap Discrete Wavelet Transform

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3 Author(s)
Li Ying ; Coll. of Comput. Sci. & Technol., Jilin Univ., Changchun, China ; Lei Na ; Ma Jian

In this paper, the maximal overlap discrete wavelet transform is used for the analysis of gene co-express network. Combined cross-correlation and the multi-resolution of wavelets, a scale-specific correlation measure is proposed, which can capture the relationship of co-expression under time-delay and local time points. The scale-specific correlation measure provide a novel method to capture more biological knowledge. Based the scale-specific correlation measure all time series gene expressions are decomposed by maximum overlap discrete wavelet transform at scale 1-4. The gene co-expression networks at each scale are constructed. The statistical features include cluster coefficients, average shortest path length and degree distribution at each scale are studied. A scale-invariant or fractal behavior for yeast gene co-expression network is investigated.

Published in:

Biomedical Engineering and Informatics, 2009. BMEI '09. 2nd International Conference on

Date of Conference:

17-19 Oct. 2009