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In view of the characteristics of human eye aberrations, a set of adaptive optics system for real-time wavefront measurement and correction is designed. The system realizes wave-front reconstruction based on the model reconstruction algorithm of Zernike polynomials by obtaining the spot pattern of human eye wave-front aberrations with the aid of Hartmann-Shack wave-front sensor and accessing to high precision centroid data by adaptive centroid detection method. Meanwhile, the need for real-time correction of different characteristics of human eye aberrations is met through the flexible adjustment of parameters of a, beta and w with the aid of closed-loop iterative control algorithm based on singular value decomposition, combined with the features influencing function matrix and human eye wave-front aberrations, with micromachined membrane deformable mirror serving as wave-front corrector. The measurement and correction of wave-front aberrations of human eyes is experimented on the platform of micro adaptive optics system, the result of which indicates that the system can meet accurate measurement and real-time correction of human eye wave-front aberrations with a wide-range application prospect in ophthalmic adaptive optics technology.