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The development situation of knowledge systems engineering discipline in domestic was reviewed firstly for clarifying the research contents and goals on knowledge systems engineering. Based on the Hall three dimensions structure and knowledge management maturity model, a methodological framework on knowledge systems engineering was established to guide the implementation of project. Secondly, according to the practical demand of support system of collaborative product design in manufacturing supply chain, the design principles of knowledge management system were analyzed. The practice shows this methodological framework could provide a clear theoretical basis and method for the research and development of knowledge management system.