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This paper reports a high-efficiency GaN HEMT power amplifier (PA) based on the inverse class-E topology. The parasitic inductance and large output capacitance of the packaged active device are used as the series inductance and compensated by a shunt inductor, respectively. The composite right/left-handed transmission line is used as a harmonic control network. For the experimental validation, an inverse class-E PA is designed using a GaN HEMT and tested with a continuous wave at 1 GHz. From the measured results, the power-added efficiency (PAE) of 78.8% with a gain of 19.03 dB is achieved at an output power of 41.03 dBm.