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An integrated volatile organic toxicants sensor with a Bluetooth device interface has been developed. The device is based on novel tuning fork sensor platform along with a wireless communication/interface technology taken in an integrated system approach. It features high sensitivity and selectivity. The sensitivity and selectivity are accomplished through the use of novel tuning fork sensor modified by design (molecularly imprinted) polymers and selective filtering. Experiments have shown that the device can detect toxic volatile organic compounds (VOCs) under high concentrations of common interferents from flavors and fragrances. Applications of the device for detection of BTEX in real-world situations such as outdoor and gas station VOCs have also been demonstrated. All these features make the device a promising candidate to be deployed in real-world applications, particularly in environmental health and air pollution studies.