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Microsystems for determining the heterogeniety of head and neck cancer cell populations by para-magnetophoresis

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6 Author(s)
Jung, Y. ; Georgia Inst. of Technol., Atlanta, GA, USA ; Wang, D. ; Chen, G. ; Shin, D.
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This paper is focused on the design, fabrication and characterization of a continuous flow magnetophoretic microseparator for the separation of selectively tagged cells using para-magnetophoresis. The microseparator was characterized experimentally using head and neck cells lines 212LN and 686LN-M4E as a case study. The microfluidic separation system can separate the selectively tagged cancer cells depending on their membrane protein expression level. Experimental results show that at flow rates of 100 muL/hr and 200 muL/hr, 86.3% and 79.0% of tagged cancer cells were attracted toward center channel respectively, while 95.1% and 87.2% of non-tagged cells remained in the side channels. Additionally, the experimental results of separating tagged cancerous cells from human blood were presented.

Published in:

Solid-State Sensors, Actuators and Microsystems Conference, 2009. TRANSDUCERS 2009. International

Date of Conference:

21-25 June 2009