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Encapsulation of microparticles and biomolecules based on layer-by-layer nanoassembly techniques with microfluidic droplet devices

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5 Author(s)
Zhongcheng Gong ; Institue for Micromanufacturing, Louisiana Tech University, Ruston, USA ; Siva Penmetsa ; Zhiguo Zheng ; Yuri Lvov
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This paper reports the encapsulation of microparticles (mu-particles) and biomolecules using the layer-by-layer (LbL) nanoassembly technique with droplet microfluidic devices. This so-called droplet-LbL microchip consists of two microfluidic droplet generators, a microfluidic droplet-merging channel and a microfluidic mixing channel. The assembly of positive-charged PDDA layer on 3T3 cells has been successfully demonstrated, resulting in their surface potential change from -25.81 mV to 40.16 mV. The successful encapsulation of negative-charged mu-particles (polymethacrylate) within FITC-labeled protamine sulphate layer is also confirmed by their fluorescence image.

Published in:

TRANSDUCERS 2009 - 2009 International Solid-State Sensors, Actuators and Microsystems Conference

Date of Conference:

21-25 June 2009