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We report on an innovative quadrupolar magnetic actuation system designed for performing immunoassays on-chip. Integrated magnetic microtips enable the retention and manipulation of functionalized superparamagnetic particles in a microfluidic channel. Actuation of dynamic bead plugs results in improved perfusion with sample solution thus enhanced analyte capture. The magnetic field parameters and kinetic properties of the bead plugs are discussed in detail. Improved protein capture efficiency is demonstrated with a model assay by means of fluorescent detection.