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Cardiomyocyte death is a critical risk factor in a variety of cardiovascular diseases. At the level of individual cardiomyocyte, cell adhesion alters at the early phase of ongoing death. In the previous study, we developed the impedance-sensing technique for real-time monitoring cardiomyocyte adhesion. In this work, we demonstrated the application of our impedance-sensing technique in regulating cell responses to chemical stimuli. The results showed that the cell detachment could be detected with our impedance-sensing technique earlier than conventional biochemical staining techniques, and it could be used to guide the precautionary removal of TNF-alpha from the cell culture to intervene in the cell responses and prevent cardiomyocytes from cell death.