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In this study, we successfully produced the chitosan microfibers using the proposed various angles of microfluidic chip, which was also been simulated. By controlling the core and sheath flow rates, we were able to generate laminar flow of different diameters from 15 mum to 40 mum. And the diameter of chitosan microfiber was measured from 20 mum to 50 mum. The microchannel of angle 30deg could produce chitosan laminar flow of a smaller diameter than the angle 60deg and angle 45deg at the fixed flow rates. Finally, the chitosan microfiber was chosen as scaffold and the schwann cell and fibroblast cell with chitosan microfibers were used for cell culture to test effect in tissue engineering application.