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OFDMA femtocells have been pointed out by the industry as a good solution not only to overcome the indoor coverage problem but also to deal with the growth of traffic within macrocells. However, the deployment of a new femtocell layer may have an undesired impact on the performance of the macrocell layer. The allocation of spectrum resources and the avoidance of electromagnetic interference are some of the more urgent challenges that operators face before femtocells become widely deployed. In this article a coverage and interference analysis based on a realistic OFDMA macro/femtocell scenario is provided, as well as some guidelines on how the spectrum allocation and interference mitigation problems can be approached in these networks. Special attention is paid to the use of self-configuration and self-optimization techniques for the avoidance of interference.