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This paper considers the problem of high-resolution remote sensing (RS) of the environment formalized in the terms of a nonlinear ill-posed inverse problem of estimation of the power spatial spectrum pattern (SSP) of the wavefield scattered from an extended remotely sensed scene via processing the discrete measurements of a finite number of independent realizations of the observed degraded data signals [single realization of the trajectory signal in the case of synthetic aperture radar (SAR)]. We address a new descriptive experiment design regularization (DEDR) approach to treat the SSP reconstruction problem in the uncertain RS environment that unifies the paradigms of maximum likelihood nonparametric spectral estimation, descriptive experiment design, and worst case statistical performance optimization-based regularization. Pursuing such an approach, we establish a family of the DEDR-related SSP estimators that encompass a manifold of algorithms ranging from the traditional matched filter to the modified robust adaptive spatial filtering and minimum variance beamforming methods. The theoretical study is resumed with the development of a fixed-point iterative DEDR technique that incorporates the regularizing projections onto convex solution sets into the SSP reconstruction procedures to enforce the robustness and convergence. For the imaging SAR application, the proposed DEDR approach is aimed at performing, in a single optimized processing, adaptive SAR focusing, speckle reduction and RS scene image enhancement, and accounts for the possible presence of uncertain trajectory deviations.