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Based on the optimization theory and product recycle and remanufacturing, a closed-loop supply chain logistics network is designed, and a mixed integer nonlinear programming (MINLP) model is constructed. According to characteristic of the model, improved differential evolution algorithm is adopt to solve the problem. As a result, the facility location problem of closed-loop supply chain logistics network and the best flow distribution on each route have been solved. In the end, the validity and feasibility of this model is validated by a concrete example, and it provide a reference model and algorithm for logistics network design of closed-loop supply chain.