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Magnetoresistive Detection of Magnetic Beads Flowing at High Speed in Microfluidic Channels

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7 Author(s)
Loureiro, J. ; INESC-MN Inst. de Eng. de Sist. e Comput. - Microsistemas e Nanotecnologias, Inst. for Nanosci. & Nanotechnol., Lisbon, Portugal ; Fermon, C. ; Pannetier-Lecoeur, M. ; Arrias, G.
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An integrated device including microfluidic channels and incorporated magnetoresistive spin valve sensors has been developed and used to detect single magnetic bead motion at cm/s velocities. The sensitivity of the system is high enough to determine the magnetic orientation, the flowing height and the speed of each particle for velocities between 10-23 mm/s and the counting capability of the device is fully working for this range of velocities and below this limit. Sensor signals (between 3-100 muVp-p) correspond to bead moments at different directions indicating a physical rotation of the beads, and a slow response (seconds) of the bead moment to magnetizing field changes. Subsequent magnetic characterization of the micron-sized beads indicates that they are composed of strongly interacting magnetic nanoparticles.

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Magnetics, IEEE Transactions on  (Volume:45 ,  Issue: 10 )