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Synthesis of Hybrid Gold/Iron Oxide Nanoparticles in Block Copolymer Micelles for Imaging, Drug Delivery, and Magnetic Hyperthermia

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5 Author(s)
Dong-Hyun Kim ; Mater. Sci. Div., Argonne Nat. Lab., Argonne, IL, USA ; Rozhkova, E.A. ; Rajh, T. ; Bader, Samuel D.
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In our study, hybrid gold/iron oxide loaded thermoresponsive micelles were synthesized for combined hyperthermia and chemotherapy, and optical imaging. Polymeric micelles made of amphiphilic block copolymer of poly(N-isopropylacrylamide-co-acrylamide)-block-poly(epsiv-caprolactone) were conjugated with gold/iron oxide particles which are self-assembled at the hydrophobic polymer core. Thermal sensitivity and magnetic and optical properties of the hybrid gold/iron oxide micelles were investigated for the combined therapy and optical imaging.

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Magnetics, IEEE Transactions on  (Volume:45 ,  Issue: 10 )