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In this letter, we investigate the effects of pansharpening (PS) applied to multispectral (MS) multitemporal images in change-detection (CD) applications. Although CD maps computed from pansharpened data show an enhanced spatial resolution, they can suffer from errors due to artifacts induced by the fusion process. The rationale of our analysis consists in understanding to which extent such artifacts can affect spatially enhanced CD maps. To this end, a quantitative analysis is performed which is based on a novel strategy that exploits similarity measures to rank PS methods according to their impact on CD performance. Many multiresolution fusion algorithms are considered, and CD results obtained from original MS and from spatially enhanced data are compared.