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Keyhole channels generally characterize rank-efficient MIMO channels, which were predicted theoretically and also observed experimentally. In this paper, we present error rate performance analysis of orthogonal space-time block codes (STBCs) in correlated keyhole multiple-input multiple-output (MIMO) channels, which is not only suitable for exponential correlation models, but also for constant correlation models. Using a moment-generation-function (MGF) based approach, we provide the exact expressions of the average symbol error rate (SER). Simulation results are provided to validate our analytical results.