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This paper presents the feasibility of applying an ultra-wideband (UWB) wireless scheme to both high data rate implantable neural recording and low data rate wearable biomedical applications. An extensive analysis on the UWB signal generation for biomedical application is discussed. A CMOS UWB transmitter has been designed, fabricated, and used in a high data rate neural recording system. A method to readily assemble a flexible UWB transmitter for wearable physiological monitoring system is also presented. An eight-channel low data rate recording system for monitoring multiple continuous electrocardiogram and electroencephalogram signals has been designed, and its test results are presented.