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Analysis on the effect of natural cerebrolysin on gene expression profile of hippocampus in rat AD model by whole genome microarray and bioinformation technologies

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6 Author(s)
Li Ying-hong ; First Affiliated Hosp. of Shenzhen Univ., Shenzhen, China ; Wu Zheng-zhi ; Li Ming ; Jia Xiu-qin
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Objective: By analyzing the effect of natural cerebrolysin (NC) on gene expression profile of rat hippocampus Alzheimer's disease (AD), to explore its molecular genetic pharmacodynamic mechanism of anti-AD. Methods: The experiment included the AD model, sham-operation and NC treated group. The changes of hippocampus gene expression profiles in the above three groups were analyzed by Affymetrix rat whole genome expression profile microarray. Results: Compared to the sham-operation group, the AD model group had 50 up-regulated genes (Fold Change > 2) and 21 down-regulated genes (Fold Change < 0.5) with significant difference. Compared to the model group, the NC treated group was found to have 5 up-regulated genes and 20 down-regulated genes with significant difference. Conclusion: NC can regulate hippocampal function, and further regulate the brain function of animals in multiple gene target points by a number of ways.

Published in:

IT in Medicine & Education, 2009. ITIME '09. IEEE International Symposium on  (Volume:1 )

Date of Conference:

14-16 Aug. 2009