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Begun with Kasturba Medical College, Manipal, India in 1953, Manipal University Health Sciences Library, India is one of the largest libraries in South East Asia. Library offers a rich array of information resources for pursuing discovery and research. The library has access to variety of e-resources, including 18 online databases, more than 2500 online journals and e-books which have been made available to library users via various interfaces. Frustrated with navigating these different interfaces, Manipal University became aware of the fact that Health Sciences Library required a solution to access all library e-resources from a single entry point. This paper goes into the details on the ERMSS software which has provided library users with a single point access for effective searching of e-resources held by library. ERMSS meets the challenge with a feature-rich system combined with a robust administrative module and enabling a single point of access to entire e-resource collection of the library.