By Topic

A Cantilever Sensor With an Integrated Optical Readout for Detection of Enzymatically Produced Homocysteine

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

4 Author(s)
Koev, S.T. ; Dept. of Electr. & Comput. Eng., Univ. of Maryland, College Park, MD, USA ; Fernandes, R. ; Bentley, W.E. ; Ghodssi, R.

Microcantilever sensors have been recognized as a promising sensor platform for various chemical and biological applications. One of their major limitations is that the measurement of cantilever displacement typically involves elaborate off-chip setups with free-space optics. An improved device, known as the optical cantilever, has been proposed recently to eliminate the external optics. The response of the optical cantilever is measured on-chip through integrated waveguides. However, this method has been previously demonstrated only for devices operating in air, whereas most chemical and biological samples are in solution state. We present the first optical cantilever capable of operation in liquid. We test it with the detection of homocysteine with a minimal concentration of 10 muM. The minimal measurable cantilever displacement and surface stress are 5 nm and 1 mN/m, respectively. The presented device will be used in studies of a homocysteine-producing bacterial pathway for the purpose of drug discovery. It can also be extended to various other chemical- or biological-sensing applications by selecting an appropriate surface coating.

Published in:

Biomedical Circuits and Systems, IEEE Transactions on  (Volume:3 ,  Issue: 6 )