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We discuss the applicability of photonic crystal fiber (PCF) with a uniform air-hole structure to high-speed and wide-band transmission over conventional telecommunication bands. We design the PCF to maximize the effective area by utilizing the macro-bending losses of the fundamental and first higher order modes (HOM) and clarify that a single-mode and low bending loss PCF can realize the largest effective areas of 133 and 157 mum2 for transmission over the 1260-1625 nm (O ~ L bands) and 1460-1625 nm (S ~ L bands) wavelength ranges, respectively. We then investigate the impact of the designed PCF on nonlinearity reduction over a wide wavelength range and show that the PCF helps to increase the maximum channel power in a wavelength division multiplexing system. We also discuss the distributed Raman amplification (DRA) characteristics of PCF with a large effective area. Our results show that we can expect to improve the signal to noise ratio with DRA in spite of the low nonlinearity of the designed PCF. Dispersion compensating fiber (DCF) with a conventional W-shaped index profile is designed to compensate for the relatively large dispersion of the PCF, and we show that the designed DCF can extend the dispersion compensation bandwidth from 1340 nm to 1650 nm for a 40 Gbit/s transmission. Finally, we clarify the applicability of the large effective area PCF with the uniform air-hole structure as a high-speed and wide-band transmission medium.