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Waveform generation by enzymatic oscillators

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3 Author(s)
Britton Chance ; University of Pennsylvania ; Kendall Pye ; Joseph Higgins

The control of cell chemistry is being investigated through a multipronged approach combining the techniques of physics, chemistry, and biology with the development of electronic instrumentation and the application of analog and digital computers. An example of such metabolic control phenomena is provided by biological oscillators involving enzymatic reactions. These oscillators, which may exist in nearly every kind of cell and even in several forms in a single cell, reveal basic instabilities in biochemical reactions and metabolic control that may be of significance to health and disease. In addition, the high-frequency oscillations observed in simple enzyme systems may be models for the longer-period rhythms that regulate the activities of nearly all biological systems.

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IEEE Spectrum  (Volume:4 ,  Issue: 8 )