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Our country's small & medium enterprises (SMEs) have been one of important pillars of national economy as a result of the rapid development of SMEs. As for SMEs, technological innovation is the only way to enhance their core competitiveness and establish competitive advantage in the market. This paper constructs the index system of risk evaluation on technological innovation of SMEs through Delphi method, which is based on the current study. Then several SMEs in Yangtze River Delta (YRD) region are evaluated by this index system, and this paper analyzes the reliability and validity of index system through the structural equation modeling (SEM). The analysis of the reliability and validity is used to be proved that the index system constructed has characteristics of high reliability and validity.