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In view of the existing problem of mixed-model assembly line balancing, a mathematical model is proposed based on two factors, which are integrated including the workstation number and the assembly line efficiency. Then a new hybrid genetic algorithm is developed for finding optimal solution of the problems. To prevent the premature convergence problem and enhance the globe-optimization capability, GA (genetic algorithms) is combined with SA (simulated annealing algorithms). The results of the simulation indicated that the hybrid algorithm has better efficiency an optimization performance.