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As a TCP-Friendly Rate Control protocol on the basis of TCP Reno's throughput equation, TFRC is designed to provide optimal service for unicast multimedia delivery over the wired Internet networks. However, when used in wireless environment, it suffers significant performance degradation. Most of the current research on this issue only focuses on the TFRC protocol itself, ignoring tightly-coupled relation between the transport layer and other network layers. In this paper, we propose a new approach to address this problem, integrating TFRC with application layer and physical layer to form a holistic design for real-time video streaming over wireless multi-hop mesh networks. The goal of the proposed approach is to achieve the best user-perceived video quality by jointly optimizing system parameters residing in different network layers, including the real-time video coding parameters at the application layer, the packet sending rate at the transport layer, and the modulation and coding scheme at the physical layer. The problem is formulated and solved as to find the optimal combination of parameters to minimize the end-to-end expected video distortion constrained by a given video playback delay. Experimental results have validated 2-4 dB PSNR gain achieved by the proposed approach in wireless multi-hop mesh networks.