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A networked integrated manufacturing system oriented product lifecycle based on multi-agent is presented, in order to meet the informatics of enterprises, solve the problem of ldquoinformation isletrdquo in manufacturing, improve design level and manufacturing quality, shorten development and production period and reduce production and service costs. The functional modules and system architecture are studied, key technologies including architecture of the networked integrated manufacturing agents, system integration, data sharing and transformation, task assignment and request information ranking of technical services are researched and a three-layer network configuration is structured based on multi-agent. Based on these, a prototype system of networked integrated manufacturing system oriented product lifecycle based on multi-agent is established. Running result of the system proves that the theories and technologies are effective.