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This paper aims at the control problem of penicillin fed-batch fermentation process, proposes a method for designing the control strategies of penicillin fed-batch fermentation process based on simulating human intelligent control theory. The object of this paper is the penicillin fermentation process. And it has established the dynamic mathematical model for specific growth rate and pH value which can reflect the fermentation process factually. The human-simulated intelligent coordinated control and human-simulated intelligent fuzzy control are incorporated into the control of the fermentation process for simulation. The fermentation fed system has been carried the dynamic decoupling control into execution. This algorithm has accomplished intelligent disposal in the fermentation process control and achieved purpose of the control for the fermentation production.