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The market competition is the product competition in the final analysis. Collaborative design chain is a system which satisfies the market and consumers with product or services. A collaborative design chain is a dynamic network system which organizations provide products and services to meet customer or marketing requirements, it is compose of core enterprise, strategic partners, suppliers, distributors and customers. This requires a meaningful exchange of product data across different partners, Information sharing is vital important to success of inter-enterprise collaborative design chain. This paper focuses on discussing information integration among mutil-enterprises, introduce structure and integration development frame of collaborative design chain, put forward a information integration model of the design chain which based on ontology and Web services, the model can satisfy demand that dynamic, heterogeneous and semantic interoperability of the collaborative design chain.